XenoScreen XL YAS
Art.No.
N32-234-Y
Unit
4 samples in 1 receptor (androgen activity) if tested in duplicates, 8 dilutions, controls. 32 samples in androgen receptor activity, duplicates, if tested in 1 dilution only. YES and YAS strains (up to 20 passages) as well as YES YAS Culture Maintenance Set need to be added separately.
Description
Ready to use Androgen Receptor Transactivation Test Kit for Identifying Androgen Receptor Agonists in endocrine disrupting chemicals, agrochemicals, cosmetics (EDC's) or in waste water. In compliance with OECD Guideline TG455.
Characteristics
- Includes all media, controls, also quality controlled plastic ware
- Number of samples per receptor acitivity (agonist only): 4 samples if tested in duplicates, 8 dilutions and 32 samples in duplicates, 1 dilution
- Excel calculation sheet is available free of charge to support result interpretation
- Includes Lyticase
- Strains are not included in the kit and are available separately.
Many endocrine disrupting chemicals adversely impact the estrogen signaling by interacting with estrogen receptors. The receptors show ligand selectivity and target gene regulation, they modulate metabolic enzymes that are critical for normal estrogen synthesis and metabolism. Typical EDC's are e.g. phytoestrogens, bisphenolics, and organochlorine pesticides. Many endocrine discrupting chemicals act through multiple mechanisms and therefore biological effects of EDCs need to be carefully interpreted.
